3D打印纳米纤维素增强聚乳酸血管支架的体外力学性能研究

doi:10.19936/j.cnki.2096-8000.20210528.009

复合材料科学与工程 ›› 2021, Vol. 0 ›› Issue (5): 61-67.DOI: 10.19936/j.cnki.2096-8000.20210528.009

3D打印纳米纤维素增强聚乳酸血管支架的体外力学性能研究

贾李涵, 李岩^*

同济大学航空航天与力学学院,上海200092

收稿日期:2020-09-14 出版日期:2021-05-28 发布日期:2021-08-04
通讯作者: 李岩(1971-),女,博士,教授,主要从事植物纤维复合材料方面的研究,liyan@tongji.edu.cn。
作者简介:贾李涵(1993-),男,硕士,主要从事3D打印复合材料方面的研究。
基金资助:
国家自然科学基金(12061130201)

IN VITRO EXPERIMENTAL STUDY ON THE MECHANICAL PROPERTIES OF VASCULAR STENTS PREPARED BY 3D PRINTING NANOCELLULOSE/POLY (LACTIC ACID) NANOCOMPOSITES

JIA Li-han, LI Yan^*

School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai 200092, China

Received:2020-09-14 Online:2021-05-28 Published:2021-08-04

摘要/Abstract

摘要： 动脉粥样硬化疾病是当今人们生命健康的巨大威胁,而血管内介入治疗是最有效的治疗方法之一。金属血管支架是治疗动脉血管疾病的主要手段,但植入血管后会导致支架血栓和支架内再狭窄等问题。生物可吸收血管支架是有望解决支架血栓和支架内再狭窄的新一代血管支架。本文采用3D打印熔融沉积成型技术,分别成型具有不同壁厚、直径,以及采用不同打印填充路径的聚乳酸血管支架和纤维素纳米纤维/聚乳酸复合材料支架,采用平面压缩法和三点弯曲法对其进行体外力学性能测试,获得支架的径向支撑性能和纵向柔顺性能。研究结果表明:相比聚乳酸支架,复合材料支架的径向支撑性能最高提升了47.6%;在相同的支架壁厚和支架直径情况下,复合材料血管支架的纵向柔顺性高于聚乳酸血管支架,提升了20.2%。此外,极差分析结果表明,壁厚对支架体外力学性能影响最大,其次是支架直径,打印填充路径对支架体外力学性能影响较小。本研究的成果为新型生物可吸收降解支架的研制提供了新的思路。

关键词: 3D打印, 纤维素纳米复合材料, 聚乳酸, 血管支架, 体外力学性能测试

Abstract: The atherosclerosis is one of the most life-threatening diseases to modern people and percutaneous coronary intervention is an effective method for solving this disease. Currently, bare metal stent (BMS) has been widely used in the clinical practice. But two severe problems may be caused by BMS, i.e. stent thrombosis (ST) and in-stent restenosis (ISR). Bioabsorbable vascular stent (BVS) is one new general vascular stent that may solve the problems caused by BMS because of its good biocompatibility and biodegradability. In this study, the bioabsorbable vascular stents of different stent thickness, stent diameter and infill pattern made by poly(lactic acid) and cellulose nanocomposites were prepared respectively by a fused deposition modeling 3D printer. The in vitro experimental test for mechanical properties of the vascular stents were performed. Planar compression method for radial support property test and three-point bending method for flexibility of the stents were performed respectively. The test results indicate that in comparison to stents made by neat poly(lactic acid), the radial support property of modified composites stents with larger radius is increased by 47.6% and the flexibility is improved by 20.2% at most. The results of range analyses indicate that the stent thickness has the most significant impact on the in vitro mechanical properties and the infill pattern has less influence on the stent mechanical properties.

Key words: 3D printing, cellulose nanocomposites, vascular stent, poly(lactic acid), in vitro test for mechanical property

中图分类号:

TB332

贾李涵, 李岩. 3D打印纳米纤维素增强聚乳酸血管支架的体外力学性能研究[J]. 复合材料科学与工程, 2021, 0(5): 61-67.

JIA Li-han, LI Yan. IN VITRO EXPERIMENTAL STUDY ON THE MECHANICAL PROPERTIES OF VASCULAR STENTS PREPARED BY 3D PRINTING NANOCELLULOSE/POLY (LACTIC ACID) NANOCOMPOSITES[J]. COMPOSITES SCIENCE AND ENGINEERING, 2021, 0(5): 61-67.

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3D打印纳米纤维素增强聚乳酸血管支架的体外力学性能研究

IN VITRO EXPERIMENTAL STUDY ON THE MECHANICAL PROPERTIES OF VASCULAR STENTS PREPARED BY 3D PRINTING NANOCELLULOSE/POLY (LACTIC ACID) NANOCOMPOSITES

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